Sterilizing-Grade Filter(PES 0.45+0.2 μm)
Product Introduction
Alioth Alipore® CHC Double-layer Polyethersulfone(PES) Filter is suitable for the sterile filtration of various process fluids. Including cartridge filter and disposable capsule filter. This filter has been rigorously validated for its sterilization performance. It features a built-in pre-filtration layer, a high flow rate, and a high capacity, thereby optimizing process efficiency and cost-effectiveness.
Product Properties
- Highly asymmetric Double-layer membrane(PES)
- High flow rates and high capacity
- Validated reliable bacterial retention
- Wide chemical compatibility
- 100% integrity tested
Typical Applications
- Buffer solution filtration
- Sterile filtration of cell culture media
- Filtration of biological intermediates and stock solutions
- Terminal sterilization filtration
- Filtration of water for pharmaceutical use solutions
Flow Characteristics
Product Characteristics
| Product Specification | Cartridge Filter (5 inch) |
Cartridge Filter (10 inch) |
Cartridge Filter (20 inch) |
Cartridge Filter (30 inch) |
Capsule Filter (5 inch) |
Capsule Filter (10 inch) |
| Dimensions Diameter Body Diameter Maximum Width Maximum Length |
69 mm |
69 mm |
69 mm |
69 mm |
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- |
| Filtration Area | 0.3 m2 | 0.6 m2 | 1.2 m2 | 1.8 m2 | 0.3 m2 | 0.6 m2 |
| Pore Size | 0.45+0.2 μm | |||||
| Structural Materials | Filter membrane: Hydrophilic polyethersulfone (PES) Supporting Layer: Polyethylene O-rings of cartridges: Silicone Liner / cartridge body: Polyethylene End caps: Polyethylene / Polycarbonate |
Filter membrane: Hydrophilic polyethersulfone (PES) Supporting Layer: Polyethylene O-rings of capsules vent: Silicone Liner / cartridge body: Polyethylene Housing : Polyethylene |
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| Bacterial Retention | ＞107 cfu /cm2 B. diminuta ( ATCC® 19146TM ) | |||||
| Maximum Tolerated Differential |
Forward: 5.0 bar（72.5 psi）@ 25°C / 3.0 bar（43.5 psi）@ 80°C Reverse: 2.0 bar（29.0 psi）@25℃ |
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| Bubble Point | ≥3520 mbar（51 psi）(wetted with H2O, 20℃, compressed air） | |||||
| Diffusion | Through a water wet membrane at 2760 mbar (40 psi) （20℃, compressed air ） | |||||
| ≤12.5 mL/min | ≤25 mL/min | ≤50 mL/min | ≤75 mL/min | ≤12.5 mL/min | ≤25 mL/min | |
| Sterilization | Steam in place: 136℃, 30 min, 30 cycles Autoclave: 131℃, 30 min, 30 cycles |
Autoclave(A&G): 131℃, 30min, 5 cycles Gamma-compatible (G): 50 kGy *Cannot be steam sterilized in-line, Pre-sterilized capsule filters must not be re-sterilized |
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| Biological Safety | All the construction components of this filter comply with the requirements for biological safety of Class VI plastics in current USP<88> | |||||
| Indirect Food Additive | The primary construction components of this filter comply with the requirements for food contact materials as stipulated in EU 1935 / 2004 / EC and FDA 21 CFR 177-182 | |||||
| Cleanliness | Cleanliness meets the requirements for nonfiber releasing filter as specified inFDA21 CFR211.72 and 210.3 (b) (5) (6), and the level of insoluble particles in rinsing liquid meets the requirements of USP< 788> | |||||
| Endotoxin | The endotoxin level of cartridge rinsing liquid is <0.25 EU/mL as indicated by gel method, which complies with the requirements of USP<85> | |||||
| TOC / Conductivity | Filtrate of this filter , TOC＜0.5 mg/L, Conductivity＜1.3 μS/cm | |||||
| Integrity | 100% has passed the integrity test | |||||
| Manufacturing Environment |
Manufactured in a Class 100,000 clean workshop | |||||
Ordering Information
Cartridge Filters
Capsule Filters
For further information, please contact us and Alioth technical team will provide a comprehensive service for your filtration process.
